Pituitary – Gonadal Axis in Men with Abdominal Obesity and Healthy Men of Different Age (Article)

Objectives: The aim of our investigation was to study the state of pituitary – gonadal system in 10 men with abdominal obesity (BMI>27; waist circumference >102 cm), in comparison with these indicators in healthy men of different age (group 1 – 22 men aged 40 – 49 years; group 2 – 12 men aged 50 – 59 years; group 3 aged 60 – 69 years).

Methods: The following parameters were determined: follicle – stimulating (FSH) and luteinizing (LH) hormones of pituitary gland as well as blood levels of estradiol, progesterone and testosterone.

Results: Analysis of results obtained showed that there were no differences between concentration of FSH and LH between patients and healthy men from group 1, and at the same time there was reliable differences between these parameters in control group 2 and 3 in comparison with obesity men (p < 0,01; < 0,05; < 0,001, respectively); level of estradiol in men with abdominal obesity was comparable with group 2 of healthy men, and concentration of progesterone and testosterone did not differ in patients with obesity and healthy men aged 60 – 69 years.

Conclusions: Thus, investigation performed manifested that men with abdominal obesity had changes in pituitary – gonadal system, comparable with those that were noted in men of more aged groups.

Posted by: Erkin Makhmudov, Dr., The Main Military Clinical Hospital of Internal Troops of the Ministry of Internal Affairs of Russian Federation, Russian Federation (05-Sep-2012)
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