Nuclear Receptors: Signaling, Gene Regulation and Cancer (X7)

Nuclear receptors (NRs) comprise a large family of ligand-regulated transcription factors that play critical roles in physiology and disease. Much of the focus has been on the nuclear actions of NRs, including interactions with coregulators, modulation of chromatin structure, and regulation of gene expression. Recent studies, however, have also suggested a role for membrane- or cytoplasmic-initiated actions of NRs and crosstalk with other cellular signaling pathways. Current studies are aimed at understanding how the ligand-dependent molecular actions of NRs, including their subcellular localization, binding across the genome, and interaction with the proteome, connect to their roles in physiological and pathophysiological processes, including hormone-regulated cancers. In addition, NRs are being explored as targets for drug development, with many compounds on the market or in ongoing clinical trials. This meeting will highlight recent breakthroughs in NR research, promote interactions between scientists from industry and academia, and provide opportunities for senior scientists to interact with younger researchers and trainees.