Description
Allosteric modulators are an emerging class of orally available small molecule therapeutic agents that may be able to offer patients better outcomes than with traditional small molecule therapies. This potential stems from their ability to offer greater selectivity and better modulatory control at disease mediating receptors. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. The advent of functional assays as the screening method of choice is leading to an increase in the number of allosteric modulators identified.
At Arrowhead s 2010 Allosteric & Orthosteric Modulator Congress, presentations will highlight key developments in the field of allosteric and orthosteric modulator drug discovery and clinical development.
