The 4th Covalent Drug Discovery and Development Summit explores innovative strategies for discovering and developing covalent drugs, focusing on targeting challenging proteins, optimizing hits, and translating candidates into effective therapies.
Key Topics
Targeting previously undruggable proteins with rational selection
Expanding covalent drugs to transcription factors and hard-to-drug proteins
Structural biology and computational challenges in covalent targeting
Identification and characterization of functional covalent hits
High-throughput proteomics and chemoproteomics platforms
Computational and machine learning approaches for drug discovery
Hit-to-lead optimization and warhead modification
Developing covalent activators and biologics for diverse indications
Pharmacokinetic profiling and clinical candidate development
Round tables and fireside discussions on target occupancy and optimization
Who should Attend
Medicinal chemists and structural biologists
Drug discovery and development researchers
Pharmacologists and proteomics specialists
Computational chemists and bioinformaticians
Biotech and pharmaceutical industry professionals
Clinical researchers focused on novel therapeutics
