Epigenetic Innovations 2013

Epigenetics is a research area of the changes in cellular phenotype or gene expression, expanding beyond oncology into inflammatory, neurological, metabolic, infectious and rare diseases.

Key Topics

• Lead optimisation and candidate biomarker identification
• Biophysical, biochemical, label-free and high-throughput screening
• Utilising DNA methylation data to elucidate the druggability of epigenetic readers, writers and erasers
• Functional analysis, validation and interpretation of data obtained using ChIP, bisulphite, chemoproteomic, single-cell and microarray assays
• Isoform-specific HDAC inhibitors for autoimmune and rheumatic diseases
• Target-based drug discovery for histone deacetylases and methyltransferases in oncology, inflammatory and infectious diseases
• Therapies in clinical development for epileptic, psychotic, rare and malignant diseases
• The role of position-effect variegation and genomic imprinting in sexually dimorphic and neurodevelopmental disorders
• Strategic acadæmia-industry and industry-industry partnering and collaborations
• The epigenomic basis and regulation of drug resistance in solid tumours