Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapies

Key Topics

• Translational strategies to facilitate clinical development of novel therapies
• Targets/pathways that are relevant to human disease and can be leveraged to promote repair and regeneration
• The interface between aging and senescence and tissue injury and fibrosis
• Recent advances in the understanding of cellular and molecular mechanisms driving tissue injury and fibrosis and their potential to be leveraged to promote tissue repair and regeneration
• Translational advances supporting the understanding of fibrotic disease and facilitating drug development: models of human disease; prognostic markers of disease susceptibility; biomarkers of disease activity; and non-invasive technologies to diagnose , prognosticate, and monitor therapeutic intervention
• How single-cell genomics has informed: cellular heterogeneity; mechanisms driving tissue injury and fibrosis; and cells/pathways that can be reprogrammed to promote repair and regeneration
• Recent advances toward developing novel fibrosis therapies