What are the major factors that limit ubiquitin proteasome function during disease pathogenesis
Can individual cellular pathways, like DNA repair, be specifically manipulated by altering the activity of ubiquitin pathway enzymes
Detailed connections between the diverse cellular pathways regulated by the ubiquitin system
How do infectious diseases impact the ubiquitin system, and can we utilize these diverse mechanisms to develop new tools and paradigms to manipulate the ubiquitin system
Emerging themes using by pathogens to subvert the ubiquitin system
The structural rules defining how individual proteins are specifically targeted by ubiquitin pathway enzymes

Ubiquitin Biology

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