Cancer and Metabolism: Pathways to the Future 2010

To encourage discussion and interaction, we`re combining outstanding and exciting science and a relaxed, pleasant environment. This meeting will be a great place for junior scientists to present their work. In order to divide, a cell needs both to increase its size, and to replicate its DNA processes that are metabolically demanding, requiring large quantities of proteins, lipids and nucleotides as well as energy. In order to support such large-scale anabolism in rapidly-dividing cancer cells, substantial amounts of metabolic building blocks, particularly glucose and amino acids, must be made available to the tumor. Yet tumors are situated in a metabolically-challenging environment where blood supply, and the supply of oxygen and other nutrients that comes with it, is scarce. Therefore, tumor cells develop a remarkably different metabolism compared to the normal tissues from which they are derived. The extent to which metabolism plays a role in tumorigenesis cannot be overstated and drugs that can selectively target these processes are likely to at least delay, if not halt tumor progression. This workshop will cover all the major aspects of metabolic transformation in cancer and will highlight potential therapeutic approaches that target cancer-specific metabolic pathways. A vibrant and stimulating atmosphere will enable free discussion and cross-fertilization among all delegates.