7th Annual Cell Line Development Europe

Key Topics

• Cell Line Engineering for Emerging Modalities
  • Stem cell engineering
  • Improving the developability of complex biotherapeutics
  • Tools for modifying cells in cell and gene therapy
• Cell Engineering
  • Engineering to increase CHO cell productivity
  • Engineering to express new cell surface receptors
  • Host cell engineering for desired quality attributes
• Modeling and Machine Learning in Cell Line Development
  • Machine learning for early identification of promising clones
  • Challenges in developing systems biology training datasets
  • Modeling metabolic pathways
• Optimizing Cell Line Development
  • Improving cell line robustness and titer
  • Automation
  • Rapid cell line development and selection
• Problems and Solutions
  • Cell line media optimization and quantification
  • Cell-free protein synthesis
  • Considerations in moving to an alternative cell line
• Emerging Technologies
  • Gene editing for development of alternative host cells
  • Application of capacitance probes for monitoring cell metabolism
  • Single cell multi-omics