Dynamics of Eukaryotic Transcription during Development (C4) 2010

Gene expression in eukaryotes is regulated primarily at the level of transcription. Although much is known about the basic building blocks required to recruit RNA polymerase II to a gene promoter and establish a pre-initiation complex, recent data reveals that a great deal of regulation occurs during transcription elongation, and involves dynamic interactions between the transcription machinery and chromatin structure. This meeting is intended to explore these recently appreciated mechanisms for gene regulation and to showcase the novel techniques that have permitted these advances. Of particular interest are the use of comprehensive, genomic approaches, and their use towards understanding the different patterns of gene expression in different model systems, including stem cells and developing tissues, as well as the application of novel molecular probing and cell imaging techniques to investigate the global nuclear architecture and its impact on gene expression.