Extracellular Matrix and Cardiovascular Remodeling (B2) 2011

In response to normal growth as well as a variety of pathophysiological signals, the cardiovascular system undergoes a series of structural and functional adaptations, collectively known as remodeling, that are directed responses to both the initial stimulus and to feed-forward changes that result from the precipitating event. Remodeling is driven by the extracellular matrix (ECM) environment, in terms of altered ECM levels, composition, and function. The purpose of this meeting is to bring together researchers, clinicians, and pharmaceutical industry representatives to 1) focus on controversies and knowledge gaps that still prevent or limit therapeutic translation; 2) borrow from other fields (particularly cancer and skin wound healing) to gain insight into ECM functions; and 3) to offer direction and stimulate progress in cardiovascular ECM research.